Whiskies are judged across the categories of taste, design, packaging and marketing in the awards, now in their 18th year.
International Spirits Challenge chairman John Ramsay, a former master blender at Famous Grouse producers Edrington, said: "After the success of last year's event, we are delighted to be bringing the competition back to Edinburgh for a second year."
Whisky is Scotland's largest international export and worth £4.2 billion to the economy, according to the Scotch Whisky Association.
The industry is one of few not to feel the pressure of the eurozone crisis thanks to booming demand from emerging markets in Latin America and Asia.
In the year to the end of June 2012, the value of Scotch whisky exports increased by 12%.