Forecasters have warned people to take extra care as snow is expected across much of the country.
Up to 10cm is predicted in Angus, Perthshire and over hills in southern Scotland, while up to 3cm could fall elsewhere in the east.
The Met Office has issued yellow warnings of snow for most parts of Scotland. It said that the Highlands, Grampian, Lothian and Borders, south-west Scotland, Central, Tayside and Fife are likely to be affected by sleet and snow.
Transport Minister Keith Brown said preparations were under way to deal with adverse weather.
He said: "Transport Scotland, Traffic Scotland and our resilience team are in regular contact with the Met Office, police, road operating companies and rail operators to ensure that adequate preparations are in place for this weekend.
"Frontline and patrol vehicles are being deployed across the network and on routes that are likely to be affected by snow, gritters will continue to operate until the snow has passed and will be further supported by additional vehicles. We stand ready to activate the resilience room and multi-agency response team if required."
"The yellow warning is fairly common over the winter months but the public should continue to check the travel bulletins or the Traffic Scotland website for the latest advice."
Forecasters said that roads are likely to be icy on Saturday morning after a cold night and the east of Scotland is expected to bear the brunt of the snow.
Paul Mott, a forecaster with MeteoGroup, the weather division of the Press Association, said: "The snow will be mostly over eastern Scotland. There will be some snowfall through mid to late morning into early afternoon. Locally there could be quite heavy snow around Perth and Angus and also in the Borders area over the hills.
"Western Scotland will see mostly rain but it could potentially be very icy through the morning."
